Nigeria, HURIWA, has asked the United Nations to visit Mazi Nnamdi Kanu, the IPOB leader.

Human Rights Writers Association of Nigeria, HURIWA, has asked the United Nations to visit Nnamdi Kanu, leader of the Indigenous People of Biafra, IPOB, in the custody of the Department of State Services, DSS.

The rights group said it was worried by some reports and allegations of torture being made by the detained IPOB leader.

Following the persistent complaints by Kanu of being maltreated in the cells of the DSS which have constantly been denied by the agency, HURIWA said it was now important that the UN, through her Country Representative, pays a monitoring visitation to the detention facility of the DSS to ascertain the veracity or otherwise of these consistent complaints by the leader of IPOB.

HURIWA said that there are allegations that the secret police is flouting Justice Binta Nyako’s order that it allows Kanu to change his clothes and has continued to starve the IPOB leader, according to his lawyer and human rights activist, Ifeanyi Ejiofor.

HURIWA said it was disconcerting that the DSS, which is a creation of the law, can deliberately flout the binding orders of a court of competent jurisdiction as alleged by the lawyers.

For this reason, the group said it was urging the United Nations, the European Union, the British Hogh Commission to visit and inspect the situation of the detainee, Kanu.

HURIWA said although it is aware that the DSS has on many occasions denied those sets of allegations made by the legal representatives of Kanu, the frequency of the complaints should merit a high profile visit by the International organisations in Nigeria such as the UN, EU and World’s democracies such as the diplomatic officials from Embassies of powerful nations with representation in Nigeria.

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Russia urge US and NATO to stop arm supply to Ukraine if they really want peace.

Russia’s Foreign Minister has urged the United States and NATO to stop supplying Ukraine with arms if they are “really interested in resolving the crisis”, Chinese state media reported Saturday.

Months into an invasion that failed in its short-term aim of capturing Kyiv, Russia is now intensifying operations in Ukraine’s Eastern Donbas Region.

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Return 500 Imo youth you arrested and sent to Abuja IPOB to Gov Hope Uzodinma.

The Indigenous People of Biafra, IPOB, has warned Governor Hope Uzodinma of Imo State to return the 500 youths arrested and taken to Abuja or risk the consequences of them loosing their patience.

IPOB is seeking independence of the old Eastern Region from Nigeria.

The fore leading pro Biafra group, also accused governor Uzodinma of inviting security operatives to arrest the Imo youths.

IPOB spokesman, Emma Powerful, urged the Governor to facilitate their return or incur the wrath of the group.

This is also one year that Hope Uzodinma and his APC party invited military to kill innocent citizens in Imo State and they arrested and abducted many people who they ferried to Abuja. We are also yet to see them.

They abducted over 500 Biafra youths in Imo State since last year, and we want those youths back for prosecution if they think they committed any crime.

We gathered through intelligence that those youths were actually being brought back from Abuja to Imo State but unfortunately Nigeria security agents who were escorting them executed them along the way of Abaji and Lokoja in Kogi State.

“We are about to exhaust our patience. Hope Uzodinma should please return those youths before we lose our patience.

Hope Uzodinma should be held responsible if anything untoward happens to our comrades.

He should not expect to conduct his daughter’s traditional wedding in Abuja while the Igbo youths he aided their abduction were executed by security agents.

The spirit of those youths won’t allow him go on cerebration spree after making many innocent families childless.

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Why Russia don’t want Finland and Sweden to join NATO?

North korea to strengthen it nuclear arsenal.

Will Bulgaria survive without Russian gas?

Woman build fence on her matrimonial bed.

Paranoia involves intense anxious or fearful feelings and thoughts often related to persecution.

What is Paranoia?

Paranoia involves intense anxious or fearful feelings and thoughts often related to persecution, threat, or conspiracy. Paranoia occurs in many mental disorders but is most often present in psychotic disorders.

Paranoia can become delusions when irrational thoughts and beliefs become so fixed that nothing (including contrary evidence) can convince a person that what they think or feel is not true. When a person has paranoia or delusions, but no other symptoms (like hearing or seeing things that aren’t there), they might have what is called a delusional disorder.

  Because only thoughts are impacted, a person with delusional disorder can usually work and function in everyday life, however, their lives may be limited and isolated.

Three main types of Paranoia

Paranoia is associated with three principal conditions:

Paranoid personality disorder – considered the mildest type. Most people with paranoid personality disorder function well despite their mistrust of the world. The attitudes and behaviors associated with this disorder, when they become obvious, are often discovered to have been present for much of the person’s life.

Delusional (paranoid) disorder – characterized by the dominance of one delusion (false belief) without any other sign of mental illness. The person’s behavior depends on which delusion they have. For example, a person who has a delusion of persecution believes that other people are spying on them or plotting to harm them in some way. Stalking can be the result of delusional (paranoid) disorder – for example, the person believes they are in a relationship with a movie star they have never met. In another case, a person may imagine they have a terrible illness, despite repeated reassurance from doctors.

Paranoid schizophrenia – considered the most severe type. It is characterized by strange delusions, such as believing that one’s thoughts are being broadcast over the radio. Hallucinations, especially bizarre ones, are also common to the condition. A person with paranoid schizophrenia often finds the world confusing and functions poorly without treatment.

Causes of paranoia

Paranoia is not always due to mental illness. Recent studies have shown that mild paranoid thoughts are fairly common in the general population.

People become paranoid when their ability to reason and assign meaning to things breaks down. We don’t know why this happens. It’s thought paranoia it could be caused by genes, chemicals in the brain or by a stressful or traumatic life event. It’s likely a combination of factors is responsible.

Mental disorders that cause paranoia include:

Paranoid personality disorder

A personality disorder is a long-standing pattern of problematic thoughts, feelings, and behavior. People with paranoid personality disorder have a tendency to assume that others will harm, deceive or take advantage of them. They may appear secretive, argumentative or cold and be difficult to get along with. This disorder is uncommon and usually improves with age so that many people recover by their 40s or 50s.

Delusional disorder

People with a delusional disorder have one delusion (a fixed, false belief) without any other symptoms of mental illness. Paranoid delusions are the most common, making people feel there is a conspiracy or they are going to be harmed. But people with a delusional disorder can also have other types of unusual beliefs.

Paranoid schizophrenia

Schizophrenia is a form of psychosis and causes people to have trouble interpreting reality. The main symptoms are hallucinations (such as hearing voices that aren’t there) and delusions (fixed, false beliefs). Some people with schizophrenia have bizarre delusions such as believing that their thoughts are being broadcast over the radio or they are being persecuted by the government. Other symptoms include confused thinking and reduced motivation for everyday tasks.

Mood disorders

Psychotic disorder and bipolar disorder can cause paranoia.

Other causes of paranoia include:

Recreational drug use: Cannabis and amphetamine abuse often causes paranoid thoughts and may trigger an episode of psychosis. Other drugs such as alcohol, cocaine, and ecstasy can also cause paranoia during intoxication or withdrawals.

Neurological disease: Diseases such as dementia (including Alzheimer’s disease), Huntington’s disease, Parkinson’s disease or brain injury can cause paranoia.

Severe trauma and stress: Some studies have found that paranoia is more common in people who have experienced severe and ongoing stress. This may include abuse in childhood, domestic violence, racial persecution or living in isolation.

Paranoia risk factors

Although no one knows the exact cause of paranoia, it seems that the following contribute to the condition.

Risk factors of paranoia included Family history of personality disorders or other mental illness, Low level of education and lower social and economic status,

Verbal, physical or sexual abuse during childhood, Neglect or an unstable/ disordered family life during childhood, being diagnosed with childhood conduct disorder and imbalance in brain chemistry and structure.

This tends to affect males more than females, and it usually starts in the early teen years or young adulthood which may be due to massive changes going on within the brain.

Symptoms of Paranoia

Paranoid symptoms may range from mild to severe. They depend on the cause but, generally, a person who is paranoid may:

Be easily offended

Find it difficult to trust others

Not cope with any type of criticism

Assign harmful meanings to other people’s remarks

Be always on the defensive

Be hostile, aggressive and argumentative

Not be able to compromise

Find it difficult, if not impossible, to ‘forgive and forget’

Assume that people are talking ill of them behind their back

Be overly suspicious – for example, think that other people are lying or scheming to cheat them

Not be able to confide in anyone

Find relationships difficult

Consider the world to be a place of the constant threat

Feel persecuted by the world at large

Believe in unfounded ‘conspiracy theories’

Complications of Paranoia

If paranoid is not treated, a person can end up with severe emotional and behavioral problems that can affect every part of his life. Such complications can include:

Depression

Alcohol and drug abuse

Self-destructive behavior

Relationship problems

Financial problems/poverty

Abuse of prescription drugs

Homelessness

Illegal acts

Inability to work or attend school

Suicidal thoughts and behavior

Involvement in violent crime

Heart and lung disease from smoking

Talk to your doctor about other complications from paranoid

How is Paranoia diagnosed?

If a person has symptoms, the doctor will begin an evaluation by performing a complete medical history and physical examination. Although there are no laboratory tests to specifically diagnose personality disorders, the doctor might use various diagnostic tests to rule out physical illness as the cause of the symptoms. For example, difficulty hearing or long-lasting substance abuse may be confused with PPD.

If the doctor finds no physical reason for the symptoms, he or she might refer the person to a psychiatrist or psychologist, health care professionals who are specially trained to diagnose and treat mental illnesses.

PPD is different from psychotic disorders such as schizophrenia, paranoid type or delusional disorder, persecutory type, in that the person with PPD lacks the perceptual distortions (for example, hearing voices) or bizarre delusional thinking (for example, being followed everywhere by the FBI).

Psychiatrists and psychologists use specially designed interview and assessment tools to evaluate a person for a personality disorder.

What treatment is available for Paranoia?

If your paranoid thoughts are causing you to distress then you may want to seek treatment. You may also be offered treatment for paranoia as part of your treatment for a mental health problem.

The first step is usually to visit your GP. Our information on seeking help for a mental health problem can help you speak to your doctor about your mental health.

Talking treatments

Talking treatments can help you understand your experiences and develop coping strategies to deal with them.

Cognitive behavioral therapy

The most common form of talking treatment for paranoia is cognitive behavioral therapy (CBT). During CBT, you will examine the way you think and the evidence for your beliefs and look for different possible interpretations. CBT can also help reduce worry and anxiety that may influence and increase feelings of paranoia.

Other talking treatments

Many other forms of talking treatments are available, including:

Psychodynamic therapy

Counseling

Family (or systemic) therapy

Arts therapies

Arts therapies can help you express how you are feeling in different ways. They can be helpful if you are having difficulty talking about your experience.

Medication

If you have a diagnosis of paranoid schizophrenia or delusional disorder, you are likely to be offered an antipsychotic drug to reduce your symptoms. Antipsychotics may reduce paranoid thoughts or make you feel less threatened by them.

If you have anxiety or depression, your GP may offer you antidepressants or minor tranquilizers. These can help you feel less worried about the thoughts and may stop them from getting worse.

Can Paranoia be prevented?

Although prevention of Paranoia might not be possible, treatment can sometimes allow a person who is prone to this condition to learn more productive ways of dealing with situations.

Poliomyelitis, commonly known as polio, is an infectious viral disease caused by the genus Enterovirus.

Introduction

Poliomyelitis, commonly known as polio, is an infectious viral disease caused by the genus Enterovirus from the Picornaviridae family. Poliomyelitis is a paralytic disease resulting from the destruction of motor neurons in the central nervous system and can lead to partial or full paralysis.

Structure of polio virus

The poliovirus is a small (22 to 33 nm), single-stranded (approximately 7,500 nucelotides), and positive sense RNA virus enclosed in a non-enveloped icosahedral protein capsid. The virus can survive in an acidic pH environment, like the gastrointestinal tract. There are three serotypes of poliovirus: PV1, PV2, and PV3. Generally, immunity to one serotype does not mean immunity to other serotypes.

Types of poliomyelitis

There are three forms of polio infections: sub-clinical, non-paralytic, and paralytic.

Sub-clinical: The most common polio infection form is sub-clinical, which accounts for approximately 95 percent of all cases. Sub-clinical infected individuals typically are asymptomatic and does not affect the central nervous system.

Non-paralytic: This form causes mild symptoms and does not result in paralysis. However, it does affect the central nervous system. This form makes up 1-5 percent of all polio cases.

Paralytic: Known as the rarest and most serious form of polio, it causes full or partial paralysis in affected individuals. Within this form, there are three types of paralysis that can occur:

Spinal polio: The virus attacks motor neurons in the spinal cord that causes paralysis in the arms and legs, and breathing problems.

Bulbar polio: The virus affects the neurons responsible for sight, taste, swallowing, and breathing.

Bulbospinal polio: The virus causes symptoms of both spinal and bulbar polio.

There is a condition called post-polio syndrome that can occur when an infected person has recovered from poliovirus and symptoms appear 35 years after.

Pathogenesis

The virus enters through the mouth, and primary multiplication of the virus occurs at the site of implantation in the pharynx and gastrointestinal tract. The virus is usually present in the throat and in the stool before the onset of illness. One week after onset there is less virus in the throat, but virus continues to be excreted in the stool for several weeks.

The virus invades local lymphoid tissue, enters the bloodstream, and then may infect cells of the central nervous system. Replication of poliovirus in motor neurons of the anterior horn and brain stem results in cell destruction and causes the typical manifestations of poliomyelitis.

The time from being infected with the virus to developing symptoms of disease (incubation) ranges from 5 – 35 days (average 7 – 14 days). Most people do not develop symptoms.

Historical information

Evidence of polymyelitis can be traced back to Ancient Egypt

1789 – British physician Michael Underwood records the first clinical description

1894 – In Vermont, the first outbreak of polio epidemic in the US occurs, with 132 cases

1908 – Scientists Karl Landsteiner and Erwin Popper are the first to identify a virus as the causative agent of polio through experiments of transmission to a monkey

1916 – Another polio epidemic occurs in the US

1921 – Franklin D. Roosevelt is diagnosed with polio at the age of 39. He inadvertently becomes the face of polio and helped change public perception on the disease.

1930s – Three strains of poliovirus are discovered

1953 – Dr. Jonas Salk and his associates develop an inactivated polio vaccine.

1955-1957 – U.S. polio incidence declines by 85-90 percent.

1979 – The last case of wild type polio in the US reported.

1980s – Post-polio syndrome identified by physicians

1981 – Publication of Poliovirus genome sequence

1999 – Inactivated polio vaccine replaces oral polio vaccine as the recommended form of polio immunization in the US.

Epidemiology

Poliomyelitis occurred worldwide, but is not limited to Asia and African continents. During 2003 the disease was endemic in 6 countries India, Nigeria, Niger, Pakistan, Afghanistan and Egypt. However importations from these endemic countries have been reported recently in other polio free countries and states. The disease is seasonal, with cases starting to increase sharply in June with peaks during July through September. Cases continue to be high in areas with low immunization coverage and poor sanitation.

Causes

Poliomyelitis is a disease caused by infection with the poliovirus. The virus spreads by:

Direct person-to-person contact

Contact with infected mucus or phlegm from the nose or mouth

Contact with infected feces

The virus enters through the mouth and nose, multiplies in the throat and intestinal tract, and then is absorbed and spread through the blood and lymph system.

Who is at risk of getting Poliomyelitis?

As is the case with many other infectious diseases, people who get polio tend to be some of the most vulnerable members of the population. This includes the very young, pregnant women, and those with immune systems that are substantially weakened by other medical conditions.

Anyone who has not been immunized against polio is especially susceptible to contracting the infection.

Additional risk factors for polio include:

Traveling to places where polio is endemic or widespread, especially Pakistan and Afghanistan

Living with someone infected with polio

Having a weak immune system

Pregnant women are more susceptible to polio, but it does not appear to affect the unborn child

Working in a laboratory where live poliovirus is kept

Symptoms of Poliomyelitis

Non-paralytic polio symptoms

Non-paralytic polio, also called abortive poliomyelitis, leads to flu-like symptoms that last for a few days or weeks. These include:

Fever

Sore throat

Headache

Vomiting

Fatigue

Back and neck pain

Arm and leg stiffness

Muscle tenderness and spasms

Meningitis – an infection of the membranes surrounding the brain

Paralytic polio symptoms

Symptoms of paralytic polio often start in a similar way to non-paralytic polio, but later progress to more serious symptoms such as:

  • A loss of muscle reflexes

Severe muscle pain and spasms

Loose or floppy limbs that are often worse on one side of the body

Possible Complications

Aspiration pneumonia

Cor pulmonale (a form of heart failure found on the right side of the circulation system)

Lack of movement

Lung problems

Myocarditis

Paralytic ileus (loss of intestinal function)

Permanent muscle paralysis, disability, deformity

Pulmonary edema

Shock

Urinary tract infections

Diagnosis of Poliomyelitis

Medical history

Medical history of the patient includes enquiry about exposure to a case of polio. This includes travelling to an area where polio in endemic, direct contact with nasal or mucus secretions of an individual with polio infection.

History or polio vaccination is also important. Inactivated injectable polio vaccine or IPV for example has an effectiveness of around 90% protection from the infection. Individuals who are vaccinated are usually protected from the infection.

Physical examination

This involves a complete checkup of the systems. The respiratory muscles are examined for function as polio affecting spinal cord and brain stem may affect respiratory muscles.

Muscle reflexes are tested. Abnormal reflexes are detected. There may be a stiff neck and stiff muscles of the back. There may be difficulty in bending the neck and difficulty in lifting the head or legs when lying flat on the back.

Acute flaccid paralysis

Acute flaccid paralysis (AFP) is a common clinical manifestation of poliomyelitis. AFP is defined as the sudden onset of flaccid paralysis in one or more limbs.

AFP is also caused by Guillain-Barré syndrome and transverse myelitis. AFP is monitored closely worldwide to detect stray cases of polio due to wild virus subtypes.

Laboratory diagnosis

Cerebrospinal fluid examination

The Cerebrospinal fluid bathes the spinal cord and the brain. This CSF is tested using a lumbar puncture. Lumbar puncture involves insertion of a long thin needle between the vertebrae. This draws out a small amount of CSF that is sent to the laboratory for evaluation.

Routine CSF examination includes assessment of cells (white blood cells, blood etc.) and levels of sugar and other chemicals in the CSF. Typically there are 10 to 200 cells/mm3 and there may be a mildly elevated protein content in CSF from 40 to 50 mg/100 ml.

Throat washing

Throat washing is taken and assessed for the virus. The washings are incubated at a favourable atmosphere in a culture media.

If the culture is positive for the virus it may be detected under microscope. Stool samples are also examined for polio virus. Isolation of virus from the cerebrospinal fluid (CSF) is diagnostic but is rarely possible.

Blood tests

Blood is tested for antibodies for polio virus. Antibodies are molecules that are produced by the body against an invading virus or bacteria.

When a person is infected with polio virus, special tests can detect the levels of polio virus specific antibodies and confirm the diagnosis.

Fingerprinting the polio virus

Once the polio virus is isolated it is tested by a special test called oligonucleotide mapping (fingerprinting) or genomic sequencing. This is essentially looking at the genetic sequence of the virus to detect if the origin of the virus is “wild type” or “vaccine like”.

Wild type virus naturally occurs in the environment and may occur as 3 subtypes – P1, P2 and P3. Vaccine like virus is derived after a spontaneous mutation of the genes of the virus in the polio vaccine.

Treatments and drugs

Because no cure for polio exists, the focus is on increasing comfort, speeding recovery and preventing complications. Supportive treatments include:

Bed rest

Pain relievers

Portable ventilators to assist breathing

Moderate exercise (physical therapy) to prevent deformity and loss of muscle function

A nutritious diet

People with major poliomyelitis may require additional treatments, including:

Physical therapy – Therapy helps to minimize damage to paralyzed muscles and to help people regain mobility as the acute illness resolves. Treatment for paralysis depends on which muscles are affected.

Measures to prevent urinary tract infections – If the bladder muscles do not contract normally, the bladder may not empty completely. This can lead to urinary infections. Using catheters to empty the bladder may be necessary, and long-term use of antibiotics is recommended in some cases.

Mechanical breathing support – When polio weakens the chest muscles so much that they cannot move the lungs (cannot breathe), people can be kept alive by placing a tube into their windpipe (the trachea). This tube is placed through an opening in the neck, called a tracheostomy. Breathing is performed by a machine called a ventilator that moves air in and out of the lungs. A catheter attached to a suction motor can remove excessive mucus through the tracheostomy tube.

Assistive devices

Splint: A splint is a device designed to keep a part of the body in a normal position or a symmetrical posture. A splint may be used to facilitate and assist movement, support weak muscles and avoid contractures and deformities.

Orthosis: An orthosis provides support for a weak body part and thus allows a person to function better, e.g. to walk. If poliomyelitis has left a child with permanent muscle weakness (paralysis), an orthosis will be needed for life. For example, if the thigh muscles (quadriceps) are too weak to straighten the child’s knee, using an orthosis may allow the child to walk.

Crutches and walkers: Crutches and walkers are used by children to support themselves during standing and walking. Walkers are very helpful for children with poor balance and weak muscles.

Wheelchair: For a few children with poliomyelitis, wheelchairs can be an important component of their rehabilitation. Wheelchairs are usually prescribed for children who are unable to walk even with assistive devices.

Crutches

Symptoms of fever, headache, back, and neck and muscle pain are relieved by using pain relievers and muscle relaxant medications. Usually NSAIDs like Ibuprofen, Diclofenac and Acetaminofen are preferred.

Aspirin is not used in children with viral infections for fear of Reye’s syndrome that causes severe irreversible liver damage.

For pain, spasm and stiffness in the muscles moist heat using warm towels and heating pads may be used.

Patients who have difficulty breathing or have paralysis of respiratory muscles may need breathing support using artificial support like ventilators.

Those with urinary tract infections need antibiotics. There may be problems in urinating due to difficulty in beginning urinating. This may lead to retention of urine.

Opioids like Morphine etc. are not prescribed as they may suppress breathing further leading to respiratory failure.

Prevention of Poliomyelitis

Prevention of polio is one of the best approaches towards the disease. Paralytic polio has no cure and may lead to death and disability.

Prevention of polio involves:

Maintenance of good hygiene to prevent transmission of the virus. This involves drinking clean water, regular hand washing and appropriate disposal of nasal and mucus secretions.

Vaccines are of two types. One is the inactivated polio vaccine (IPV) and the other oral polio vaccine (OPV).

IPV vaccine for polio

IPV also called Salk vaccine, is injected in the leg or arm, depending on age. IPV is given to a child at age of 2, 4 and 6-18 months. A booster dose is needed at 4-6 years.

Adults usually do not need polio vaccine if they have been vaccinated as children. However, those who are travelling to a place where there is a polio outbreak, those working with samples of polio virus in a laboratory and those living in contact with a polio virus infected person may need to be vaccinated.

Pregnant women, those with a suppressed immunity and those with HIV require to be vaccinated with IPV. Adult regimen of vaccination is first dose at any time followed by second dose 1 to 2 months later and third dose 6 to 12 months after the second.

IPV can cause an allergic reaction in some people. Because the vaccine contains trace amounts of the antibiotics streptomycin, polymyxin B and neomycin, it shouldn’t be given to anyone who’s had a reaction to these medications.

Signs and symptoms of an allergic reaction usually occur within minutes to a few hours after the shot and may include:

Difficulty breathing

Weakness

Hoarseness or wheezing

Rapid heart rate

Hives

Dizziness

Unusual paleness

Swelling of the throat

OPV vaccine for polio

OPV is also called Sabin vaccine. It contains live but much weakened polio virus given as oral drops.

It helps the receiver’s immune system to recognize the virus and create antibodies against it so that when they are faced with the actual infection they may be able to fight it.

Another benefit of OPV is that children vaccinated with the drops excrete the vaccine virus that is much weakened.

The contacts of the child who are not vaccinated receive the dose of the vaccine virus second hand from them. This contains the polio outbreaks and is important for eradication of polio.